I’ve helped plenty of clients deal with this dilemma. So let me just save you from a 3000-word answer and tell you straight up…
Yes. Given the choice, you should always use the Oxford Comma in your brand's web and blog copy.
Now stop overthinking it and plaster that sweet, sweet Oxford Comma all over your website and marketing materials.
Jokes aside, the Oxford Comma isn’t going to have a huge impact on your brand’s overall success. Your audience is NOT overthinking this. They just want to throw their support behind a top-notch company that has its shit together.
So whether you choose to use the Oxford Comma or not, just be consistent about it.
Make the call. Add the editorial decision in your brand’s content style guide. And get back to creating awesome copy and content.